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A real-time three-dimensional echocardiographic validation of an intracardiac electrogram-based method for optimizing

Maria Cristina Porciani1, Carmelo Massimiliano Rao, Matteo Mochi

  • 1Clinica Medica Careggi, Florence, Italy. cporciani@hotmail.com

Pacing and Clinical Electrophysiology : PACE
|January 10, 2008
PubMed

Insights

A new intracardiac electrogram (IEGM) method simplifies cardiac resynchronization therapy (CRT) optimization. This IEGM-based approach effectively reduces left ventricular (LV) dyssynchrony and enhances systolic function in CRT patients.

Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Cardiac resynchronization therapy (CRT) optimization improves hemodynamics but is time-consuming.
  • A novel method using intracardiac electrograms (IEGM) for CRT optimization has been developed.
  • Real-time 3D echocardiography (RT3DE) can assess CRT's impact on left ventricular (LV) function.

Purpose of the Study:

  • To evaluate the effectiveness of IEGM-based CRT optimization.
  • To assess improvements in LV asynchrony and performance using RT3DE.

Main Methods:

  • Prospective study of 20 patients with CRT.
  • RT3DE performed before and after IEGM optimization.
  • Assessed asynchrony using Tmsv 16-SD and Tmsv 12-SD; evaluated LV volumes, ejection fraction, stroke volume, MPI, and timing intervals.

Main Results:

  • IEGM optimization significantly decreased Tmsv 12-SD and Tmsv 16-SD.
  • Left ventricular ejection fraction and stroke volume improved significantly.
  • Filling time/RR and ejection time/RR increased, and MPI improved post-optimization.

Conclusions:

  • A simple IEGM-based method effectively optimizes CRT.
  • This method reduces LV dyssynchrony.
  • Systolic function is improved in CRT patients following IEGM-based optimization.
Abstract

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