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Blood transfusion is associated with increased resource utilisation, morbidity and mortality in cardiac surgery

Bharathi H Scott1, Frank C Seifert, Roger Grimson

  • 1Department of Anesthesiology, SUNY at Stony Brook, New York 11794-8480, USA. bharathi.scott@stonybrook.edu

Annals of Cardiac Anaesthesia
|January 10, 2008
PubMed

Insights

Blood transfusions in coronary artery bypass graft (CABG) surgery patients significantly increase time to extubation, intensive care unit length of stay (ICULOS), and postoperative length of stay (PLOS). Transfused patients also experience higher morbidity and mortality rates.

Area of Science:

  • Cardiovascular Surgery
  • Transfusion Medicine
  • Healthcare Resource Utilization

Background:

  • Coronary artery bypass graft (CABG) surgery is a major cardiovascular procedure.
  • The impact of perioperative blood transfusions on patient outcomes and resource use in CABG is a critical area of study.

Purpose of the Study:

  • To investigate the effects of blood transfusion on resource utilization, morbidity, and mortality in patients undergoing CABG surgery.
  • To analyze the relationship between the number of packed red blood cell (PRBC) units transfused and postoperative length of stay (PLOS).

Main Methods:

  • Retrospective observational study of 1746 consecutive patients undergoing primary CABG.
  • Data collected on demographics, blood transfusion status, resource utilization (time to extubation, ICULOS, PLOS), morbidity, and mortality.
  • Statistical analyses included partial correlation coefficients and linear regression models.

Main Results:

  • Transfused patients had significantly longer time to extubation (8.0h vs 4.3h), ICULOS (1.6d vs 1.2d), and PLOS compared to non-transfused patients (P
  • Postoperative complications and 30-day hospital mortality were significantly higher in the transfused group (3.1% vs 0%, P
  • PLOS increased with the number of PRBC units transfused.

Conclusions:

  • Blood transfusion in CABG patients is associated with increased resource utilization, including longer mechanical ventilation and hospital stays.
  • Transfusion independently predicts increased postoperative morbidity and mortality following CABG surgery.
  • Minimizing blood transfusions in CABG patients may improve outcomes and reduce healthcare costs.

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