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Etoricoxib-induced erythema-multiforme-like eruption.
Laurence Thirion1, Arjen F Nikkels, Gérald E Piérard
1Department of Dermatopathology, University Medical Center of Liège, Liège, Belgium.
Dermatology (Basel, Switzerland)
|January 10, 2008
Summary
Etoricoxib, a selective COX-2 inhibitor, is generally safe but can cause rare skin reactions. This is the first reported case of etoricoxib causing an erythema multiforme-like eruption.
Area of Science:
- Pharmacology
- Dermatology
- Drug Safety
Background:
- Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor.
- It is known for a potentially improved safety profile compared to earlier COX-2 inhibitors.
- Previous inhibitors include celecoxib, rofecoxib, and valdecoxib.
Observation:
- A case of erythema multiforme-like eruption is presented.
- This reaction was associated with the use of etoricoxib.
- This is the first documented instance of such a reaction linked to etoricoxib.
Findings:
- Etoricoxib can induce erythema multiforme-like skin reactions.
- The safety profile of etoricoxib may include rare dermatological adverse events.
- This finding contrasts with its generally favorable safety reports.
Implications:
- Clinicians should be aware of potential rare skin reactions with etoricoxib.
- Further pharmacovigilance may be needed for selective COX-2 inhibitors.
- This case highlights the importance of reporting all adverse drug events.
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