Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A novel leishmanicidal labdane from Polyalthia macropoda.

P Richomme1, M C Godet, F Foussard

  • 1C.E.P.M., Faculté de Pharmacie, Angers, France.

Planta Medica
|December 1, 1991
PubMed
Summary

A novel labdanic diterpene was isolated from Polyalthia macropoda stem bark. This compound exhibits biological activity against Leishmania donovani donovani, a parasite causing leishmaniasis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aza-capped cyclodextrins for intra-cavity metal complexation.

Chemical communications (Cambridge, England)·2017
Same author

Vibrational dynamics (IR, Raman, NRVS) and a DFT study of a new antitumor tetranuclearstannoxane cluster, Sn(iv)-oxo-{di-o-vanillin} dimethyl dichloride.

Physical chemistry chemical physics : PCCP·2016
Same author

Out-of-equilibrium dynamics of photoexcited spin-state concentration waves.

Faraday discussions·2015
Same author

Extract from Mimosa pigra attenuates chronic experimental pulmonary hypertension.

Journal of ethnopharmacology·2013
Same author

Aperiodic spin state ordering of bistable molecules and its photoinduced erasing.

Physical review letters·2013
Same author

Lipase-catalyzed synthesis of two new antioxidants: 4-O- and 3-O-palmitoyl chlorogenic acids.

Biotechnology letters·2010

Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Parasitology

Background:

  • Polyalthia macropoda (Annonaceae) is a plant species with potential medicinal properties.
  • Diterpenes are a class of natural products with diverse biological activities.
  • Leishmania donovani donovani is a protozoan parasite responsible for visceral leishmaniasis.

Purpose of the Study:

  • To isolate and characterize a new diterpene from the stem bark of Polyalthia macropoda.
  • To evaluate the biological activity of the isolated compound against Leishmania donovani donovani.

Main Methods:

  • Phytochemical investigation of Polyalthia macropoda stem bark extract.
  • Spectroscopic techniques (NMR, MS) for structural elucidation of the isolated compound.
  • In vitro bioassays to assess antileishmanial activity against Leishmania donovani donovani promastigotes.

Related Experiment Videos

Main Results:

  • A new labdanic diterpene, (4S,9R,10R) methyl 18-carboxy-labda-8,13(E)-diene-15-oate, was successfully isolated and identified.
  • The isolated diterpene demonstrated significant biological activity against Leishmania donovani donovani promastigotes.

Conclusions:

  • The stem bark of Polyalthia macropoda is a source of novel diterpenoids.
  • The newly identified labdanic diterpene possesses antileishmanial properties, suggesting its potential for developing new anti-leishmanial drugs.