Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aza-capped cyclodextrins for intra-cavity metal complexation.

D Sechet1, Z Kaya, T-A Phan

  • 1Laboratoire de Chimie Inorganique Moléculaire et Catalyse, Institut de Chimie de Strasbourg, UMR 7177 CNRS, Université de Strasbourg, 4, rue Blaise Pascal, CS 90032, 67081 Strasbourg cedex, France. dmatt@unistra.fr.

Chemical Communications (Cambridge, England)
|October 13, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of ISB 1442, a CD38 and CD47 bispecific biparatopic antibody innate cell modulator for the treatment of multiple myeloma.

Nature communications·2024
Same author

Silibinin and ellagic acid increase the expression of insulin receptor substrate 1 protein in ultraviolet irradiated rat skin.

Biotechnic & histochemistry : official publication of the Biological Stain Commission·2020
Same author

Doubled haploid plant production from unpollinated ovules of sugar beet (Beta vulgaris L.).

Plant cell reports·2019
Same author

Late-Onset Lung Metastasis in Rectum Cancer Can Be Confused with Primary Lung Cancer; a Case Report and Literature Review.

Journal of gastrointestinal cancer·2019
Same author

Successful Treatment of Renal Infiltration Complicated by Atypical Hemolytic Uremic Syndrome in a Leukemic Child.

Indian journal of nephrology·2018
Same author

Recombinant FVIIa therapy for heavy menstrual bleeding in patients with severe FV deficiency.

Haemophilia : the official journal of the World Federation of Hemophilia·2018

Researchers synthesized novel aza-capped, methylated cyclodextrins (CDs) with unique nitrogen inversion properties. These modified CDs act as confining ligands, enabling intra-cavity metal complexation and supramolecular helix formation.

Area of Science:

  • Supramolecular Chemistry
  • Organic Synthesis
  • Coordination Chemistry

Background:

  • Cyclodextrins (CDs) are versatile macrocycles with a hydrophobic cavity and hydrophilic exterior.
  • Modifying CDs can alter their host-guest properties and introduce new functionalities.
  • Controlling nitrogen inversion in cyclic amines is crucial for designing ligands with specific geometries.

Purpose of the Study:

  • To synthesize novel aza-capped, methylated cyclodextrins.
  • To investigate the conformational properties of the modified CDs, specifically nitrogen inversion.
  • To explore the potential of these modified CDs as ligands for metal complexation and supramolecular assembly.

Main Methods:

  • Synthesis of aza-capped, methylated CDs using 2-nitrobenzenesulfonamide with dimesylated CDs or diol analogues.

Related Experiment Videos

  • Mitsunobu reaction conditions and deprotection with thiophenol for functionalization.
  • Grafting a methyl pyridine substituent onto the secondary amine nitrogen.

    • Main Results:

    • High yields of aza-capped, methylated cyclodextrins were achieved.
    • The tertiary amine on the α-CD scaffold exhibited restricted nitrogen inversion at room temperature.
    • The modified CDs functioned as confining ligands, facilitating intra-cavity metal complexation.
    • Formation of supramolecular helices was promoted by the modified CDs.

    Conclusions:

    • Novel aza-capped, methylated cyclodextrins with restricted nitrogen inversion were successfully synthesized.
    • These modified CDs serve as effective confining ligands for metal complexation.
    • The unique properties of these CDs open avenues for creating novel supramolecular structures, including helices.