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Updated: Jul 8, 2026
Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
Published on: May 28, 2017
Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models
1Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Goettingen, Germany. owirths@uni-goettingen.de
Abstract:
In this commentary, we accent the accumulating evidence for motor impairment as a common feature of early Alzheimer's disease (AD) pathology. In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD-associated genes like tau or amyloid precursor protein.
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