Related Experiment Videos
Pulmonary intestinal-type adenocarcinoma
Ryo Maeda1, Noritaka Isowa, Hideyuki Onuma
1Division of Thoracic Surgery, Matsue Red Cross Hospital, 200 Horomachi, Matsue, Shimane 690-8506, Japan. ryomaedamatsue@yahoo.co.jp
Interactive Cardiovascular and Thoracic Surgery
|January 11, 2008
Summary
This case report details a rare intestinal-type adenocarcinoma found in the lung of a 69-year-old male. Diagnosis involved imaging and cytology, confirmed by VATS surgery and histopathology.
Area of Science:
- Pulmonology
- Oncology
- Surgical Pathology
Background:
- Primary pulmonary adenocarcinomas can exhibit diverse histological subtypes.
- Intestinal-type adenocarcinoma (ITAC) is an uncommon subtype of lung adenocarcinoma.
- Accurate subtyping is crucial for prognosis and treatment strategies.
Observation:
- A 69-year-old male presented with a 2.5 cm right lower lobe lung nodule detected via CT and PET scans.
- The nodule showed high (18)F-fluorodeoxyglucose uptake, and sputum cytology was positive for adenocarcinoma.
- Video-assisted thoracic surgery (VATS) was performed for resection and lymph node dissection.
Findings:
- Histopathology revealed a tumor with tall columnar cells resembling intestinal epithelium and colorectal carcinoma.
- Immunohistochemistry showed positivity for cytokeratin 7 (CK7) and thyroid transcription factor-1 (TTF-1).
- Cytokeratin 20 (CK20) staining was negative, supporting a primary pulmonary origin.
Implications:
- This case highlights the importance of recognizing rare pulmonary ITAC.
- The diagnostic workup included advanced imaging, cytology, and detailed histopathological analysis.
- Understanding the immunophenotype (CK7+/TTF-1+/CK20-) aids in differentiating primary lung ITAC from metastatic colorectal adenocarcinoma.
Related Concept Videos
01:07Intestinal Obstruction II: Pathophysiology
Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
01:29Intestinal Obstruction I: Introduction
Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
01:14Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
01:23Renewal of Intestinal Stem Cells
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
01:24Cellular Adaptation IV: Dysplasia and Metaplasia
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...