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Updated: May 6, 2026
11:36
A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
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Peptide YY
Keval Chandarana1, Rachel Batterham
1Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London, WC1E 6JJ, UK.
Current Opinion in Endocrinology, Diabetes, and Obesity
|January 11, 2008
Summary
Peptide YY (PYY) influences energy balance and appetite. Emerging research shows PYY also affects food reward, suggesting the PYY system could be a novel therapeutic target for obesity treatment.
Area of Science:
- Endocrinology
- Neuroscience
- Metabolic Regulation
Background:
- Peptide YY (PYY) is a gut hormone involved in appetite regulation.
- Recent studies investigate PYY's role in energy homeostasis and its hedonic effects.
- The therapeutic potential of targeting the PYY system for metabolic disorders is under evaluation.
Purpose of the Study:
- To review current research on peptide YY's effects on energy homeostasis.
- To highlight the newly discovered hedonic effects of PYY.
- To assess the therapeutic viability of the PYY system for obesity.
Main Methods:
- Review of recent scientific literature on PYY and energy balance.
- Analysis of studies on exogenous and endogenous PYY actions.
- Examination of functional imaging and rodent studies on PYY's neural targets and behavioral effects.
Main Results:
- Exogenous PYY3-36 acts as an anorectic agent, promoting weight loss in obese rodents and humans.
- Endogenous PYY plays a role in regulating energy homeostasis.
- PYY3-36 activates key brain regions including the hypothalamus, brainstem, and orbitofrontal cortex, influencing reward processing and reducing motivation for high-fat foods.
Conclusions:
- Peptide YY is integral to the regulation of metabolism.
- The hedonic effects and observed weight-reducing properties of PYY suggest its system as a potential therapeutic target for obesity.
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