Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MHC class I in activity-dependent structural and functional plasticity.

Lisa M Boulanger1

  • 1Department of Biological Sciences, Pacific Hall 1212A, MC 0366, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. lboulanger@ucsd.edu

Neuron Glia Biology
|January 11, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adeno-associated virus-induced neurotoxicity is prevented by CpG depletion.

Molecular therapy. Advances·2026
Same author

Adeno-Associated Virus-Induced Neurotoxicity is Prevented by CpG Depletion.

bioRxiv : the preprint server for biology·2025
Same author

Systems neuroimmunology: current bottlenecks, research priorities and future directions.

Nature immunology·2025
Same author

An innate immune response to adeno-associated virus genomes decreases cortical dendritic complexity and disrupts synaptic transmission.

Molecular therapy : the journal of the American Society of Gene Therapy·2024
Same author

Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins.

BMC immunology·2016
Same author

Expression and alternative splicing of classical and nonclassical MHCI genes in the hippocampus and neuromuscular junction.

Molecular and cellular neurosciences·2016
Same journal

Release of neurotransmitters from glia.

Neuron glia biology·2012
Same journal

Analysis of glutathione S-transferase genes polymorphisms and the risk of schizophrenia in a sample of Iranian population.

Neuron glia biology·2012
Same journal

TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation.

Neuron glia biology·2012
Same journal

ATP derived from astrocytes modulates memory in the chick.

Neuron glia biology·2012
Same journal

Exposure to environmental enrichment prior to a cerebral cortex stab wound attenuates the postlesional astroglia response in rats.

Neuron glia biology·2012
Same journal

Direct and glia-mediated effects of GABA on development of central olfactory neurons.

Neuron glia biology·2012
See all related articles

Major histocompatibility complex (MHC) class I proteins in neurons are crucial for brain development and plasticity. Their expression dynamically responds to electrical activity, influencing synaptic strength and neuronal connectivity.

Area of Science:

  • Neuroscience
  • Immunology
  • Molecular Biology

Background:

  • Major histocompatibility complex (MHC) class I proteins are key in adaptive immunity.
  • The brain was considered immune privileged due to a lack of neuronal MHC class I.
  • MHC class I proteins are expressed in normal, uninfected neurons and their levels are dynamic.

Purpose of the Study:

  • To investigate the novel role of MHC class I in neuronal function.
  • To explore the dynamic regulation of MHC class I in the brain.
  • To understand how MHC class I translates electrical activity into synaptic changes.

Main Methods:

  • Analysis of MHC class I expression in developing and adult brains.
  • Investigating the regulation of MHC class I by neuronal electrical activity.
Keywords:
LTDLTPhippocampusimmuneremodeling

Related Experiment Videos

  • Studying the functional requirement of MHC class I in activity-dependent brain events.

    • Main Results:

    • MHC class I expression in neurons is dynamic and activity-dependent.
    • MHC class I is essential for specific activity-dependent events in brain development.
    • MHC class I plays a role in adult brain plasticity and response to injury.

    Conclusions:

    • MHC class I proteins have a novel function in the brain beyond immune surveillance.
    • Neuronal MHC class I translates electrical activity into synaptic strength and connectivity.
    • MHC class I is a critical regulator of brain development, plasticity, and repair.