[An experimental research on the acute lung injury induced by endotoxin]

Using a goat endotoxin model with chronic lung lymph fistula, we continuously measured lung lymph flow (QL), lymph to plasma protein ratio (L/P), pulmonary arterial pressure (Ppa) and the level of thromboxane B2 in plasma and lymph. We also observed the changes of ultrastructure in leukocyte and pulmonary parenchyma. It showed that the alteration can be divided into two intervals: phase I is characterized by the abrupt onset of pulmonary hypertension and in phase II, the capillary permeability increased predominantly. It was suggested that this model is a good research tool for studying adult respiratory distress syndrome (ARDS).