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Updated: Jul 8, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Gamma-secretase regulates VEGFR-1 signalling in vascular endothelium and RPE
Michael E Boulton1, Jun Cai, Maria B Grant
1Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas 77550, USA. boultonm@utmb.edu
Abstract:
In conclusion, gamma-secretase is expressed in both retinal microvascular endothelial cells and RPE cells and is able to elicit regulated intramembrane proteolysis of VEGFR1. Furthermore, gamma-secretase regulates the translocation of the intracellular domain of VEGFR1 as well as full length VEGFR1 in both cell types. Gamma-secretase is clearly able to act as a potent negative regulators of VEGFR2 induced in vitro angiogenesis but its role in the RPE has yet to be elucidated. We conclude that gamma-secretase may offer a therapeutic target for the treatment of both retinal and choroidal neovascularization.
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