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[Experimental infection with bovid herpesvirus 2]
Veterinarno-Meditsinski Nauki
|January 1, 1976
Summary
Experimental Bovid Herpesvirus 2 infection in heifers caused urticarial eczema and febrile reactions. Infected animals developed immunity, showing resistance to homologous virus challenge 80 days post-infection.
Area of Science:
- Veterinary Virology
- Immunology
- Dermatology
Context:
- Bovid Herpesvirus 2 (BoHV-2) is a significant pathogen in cattle.
- Understanding BoHV-2 pathogenesis and immune response is crucial for disease control.
- This study investigates an experimental infection model in Bulgaria.
Purpose:
- To characterize the clinical manifestations and hematological changes following experimental BoHV-2 infection in heifers.
- To evaluate the antibody response and homologous viral resistance after infection via different routes.
- To assess the duration of immunity induced by experimental BoHV-2 infection.
Summary:
- Heifers were infected with BoHV-2 (strain KOS/Haskovo) via intradermal, intranasal, and intravenous routes.
- Clinical signs included urticarial eczema, fever, leukopenia, erythropenia, and oligochromemia, irrespective of infection route.
- Intravenous inoculation resulted in the highest virus-neutralizing antibody titers by day 30. All infected heifers were resistant to homologous virus challenge on day 80.
Impact:
- Provides insights into the clinical presentation and hematological impact of BoHV-2 infection.
- Demonstrates the development of protective immunity following experimental infection.
- Informs veterinary strategies for managing and preventing BoHV-2 outbreaks in cattle populations.