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Updated: Jul 8, 2026
08:59
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
[Methods and models for percutaneous absorption studies of organophosphates]
I Boudry1, Y Trescos, V Vallet
1Centre de recherches du service de santé des armées, département de toxicologie, 24, avenue du Maquis-du-Grésivaudan, B.P. 87, 38702 La Tronche cedex, France. iboudry@crssa.net
Pathologie-Biologie
|January 15, 2008
Summary
Organophosphates are toxic compounds that readily penetrate skin. Understanding their toxicokinetics via in vivo and ex vivo models is crucial for developing effective topical skin protectants.
Area of Science:
- Toxicology
- Dermal Absorption
- Pharmacokinetics
Context:
- Organophosphates pose significant health risks due to high toxicity.
- Percutaneous absorption is the primary route of organophosphate exposure.
- Development of effective topical skin protectants is critical for exposed populations.
Purpose:
- To review experimental approaches for predicting percutaneous penetration of organophosphates.
- To analyze the relevance and reliability of in vivo and ex vivo skin models.
- To inform the development of protective formulations against organophosphate exposure.
Summary:
- This review presents in vivo and ex vivo experimental methods used to assess organophosphate percutaneous penetration.
- It critically evaluates the suitability and dependability of various cutaneous models for toxicological studies.
- Key toxicokinetic parameters for dermal absorption are discussed in relation to model systems.
Impact:
- Provides a foundation for selecting appropriate models to study dermal exposure to toxic compounds.
- Aids in the development of advanced topical formulations for enhanced skin protection.
- Contributes to risk assessment and mitigation strategies for organophosphate exposure.
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