[Bilateral papillary necrosis during indinavir treatment]
Josaphat Iba-Ba1, Jean Cyr Yombi, Etienne Danse
1Service de médecine interne A, Centre Hospitalier de Libreville, B.P. 2228, Libreville, Gabon. ibabajose@yahoo.fr
Presse Medicale (Paris, France : 1983)
|January 15, 2008
Summary
Continuous protease-inhibitor therapy with indinavir can cause rare kidney damage called papillary necrosis. This condition, affecting the renal medulla and papillae, was reversible with treatment interruption and hydration.
Area of Science:
- Nephrology
- Pharmacology
Background:
- Papillary necrosis is renal medulla and papillae ischemia from various causes.
- It is a rare adverse effect of indinavir, a protease inhibitor.
Observation:
- A case study of a patient who developed bilateral papillary necrosis during indinavir therapy.
- The condition resolved after discontinuing indinavir and increasing fluid intake.
Findings:
- Indinavir-induced papillary necrosis is a potentially reversible cause of kidney injury.
- Prompt recognition and intervention can prevent permanent renal damage.
Implications:
- Highlights the importance of monitoring renal function in patients on long-term indinavir.
- Suggests that early detection and management can mitigate indinavir-associated nephrotoxicity.
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