Related Experiment Video
Updated: Jul 8, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems
Nora Benaamane1, Bellara Nedjar-Kolli, Yamina Bentarzi
1Faculty of Chemistry, University of Sciences and Technology Houari Boumédiène, Algiers, Algeria.
Abstract:
Cyclisation of pyrazolo-beta-enaminones 3 readily obtained from 4-aceto acetyl pyrazol 2 with triphosgene led to the formation of N-substituted pyrazolo-1,3-oxazin-2-ones 4 in good yields. Estimation of pharmacotherapeutic potential, possible molecule mechanisms of action, toxic/side effects and interaction with drug-metabolizing enzymes were made for synthesised compounds on the basis of prediction of activity spectra for substances (PASS) prediction results and their analysis by PharmaExpert software. COX inhibition predicted by PASS was confirmed by experimental evaluation.
Related Concept Videos
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
