Related Experiment Video
Updated: Jul 8, 2026

A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection
Published on: August 14, 2019
New (fluorescent) light on poliovirus entry
1Division of Infectious Diseases, Children's Hospital of Philadelphia, Abramson Research Center 1202E, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA. bergelson@email.chop.edu
Abstract:
To initiate infection, poliovirus must release its RNA genome into the cytoplasm of a target cell, a process called 'uncoating'. How this occurs has remained uncertain, despite studies over several decades. Two new studies re-address the question of poliovirus entry. The results suggest that poliovirus enters different cells by different mechanisms, and point to a role for virus-induced intracellular signals in the process.

