Related Experiment Video

Updated: Jul 8, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Prooxidant-antioxidant balance as a new risk factor in patients with angiographically defined coronary artery disease

Daryoush Hamidi Alamdari1, Majid Ghayour-Mobarhan, Shima Tavallaie

  • 1Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.

Clinical Biochemistry
|January 15, 2008
PubMed

Insights

The prooxidant-antioxidant balance (PAB) is elevated in patients with coronary artery disease (CAD). This PAB value shows potential as a novel cardiovascular risk factor, warranting further investigation.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Oxidative Stress Research

Background:

  • Oxidative stress plays a role in cardiovascular disease pathogenesis.
  • The prooxidant-antioxidant balance (PAB) is a marker of oxidative stress.

Purpose of the Study:

  • To determine the PAB in patients with coronary artery disease (CAD).
  • To evaluate the PAB value as a potential cardiovascular risk factor.

Main Methods:

  • A modified PAB assay was used.
  • PAB levels were measured in 61 CAD+ patients and 63 healthy controls.
  • Correlations with clinical parameters were analyzed.

Main Results:

  • Patients with CAD exhibited significantly higher PAB values compared to controls.
  • PAB correlated positively with systolic and diastolic blood pressure, smoking, fasting blood sugar, and serum urea.
  • PAB correlated negatively with serum creatinine and bilirubin.

Conclusions:

  • The PAB value may serve as a valuable cardiovascular risk factor.
  • Further clinical research is necessary to confirm the PAB value's clinical utility in risk assessment.
Abstract

More Related Videos

Alternative Methods for the Detection of Superoxide Anion Generation in Platelets06:35

Alternative Methods for the Detection of Superoxide Anion Generation in Platelets

Published on: March 29, 2024

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...