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Related Experiment Videos

Caries prevention--fluoride.

B H Clarkson1

  • 1School of Dental Medicine, University of Connecticut Health Center.

Advances in Dental Research
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Fluoride effectively controls dental caries by influencing demineralization and remineralization, but its use requires careful management of concentrations and exposure times to avoid harm. Understanding fluoride

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Area of Science:

  • Dental science
  • Pharmacology
  • Public Health

Background:

  • Fluoride's role in dental hard tissue demineralization and remineralization is well-established.
  • Fluoride interferes with acid production by cariogenic bacteria, a key factor in caries development.
  • Inappropriate fluoride concentrations or exposure periods can lead to physiological harm.

Purpose of the Study:

  • To review the mechanism of action and pharmacokinetics of fluoride for appropriate clinical application.
  • To emphasize that fluoride controls, rather than prevents, dental caries.
  • To discuss the systemic and topical administration of fluoride, including benefits and drawbacks.

Main Methods:

  • Literature review examining systemic and topical fluoride administration.

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  • Analysis of fluoride's effects on dental hard tissues and cariogenic bacteria.
  • Discussion of fluoride concentrations, exposure periods, and resulting compounds (calcium fluoride, fluorhydroxyapatite).

    • Main Results:

    • Fluoride significantly impacts dental demineralization and remineralization processes.
    • Systemic fluoride administration (water fluoridation, supplements) and topical applications (dentifrices) offer caries control benefits.
    • Potential for fluoride toxicity exists with improper administration, highlighting the need for controlled use.

    Conclusions:

    • Appropriate clinical use of fluoride requires a thorough understanding of its mechanism of action and pharmacokinetics.
    • Fluoride is a crucial agent for caries control, but its application must be carefully managed to optimize benefits and minimize risks.
    • Balancing fluoride concentrations and exposure times is essential for effective and safe dental caries management.