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Updated: Jul 8, 2026

In-Nucleus Hi-C in Drosophila Cells
Published on: September 15, 2021
Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks
1Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. rongy@mail.nih.gov
Abstract:
Telomere caps prevent chromosome ends from being recognized as DNA double-strand breaks (DSBs). Unlike most organisms studied, the telomere-capping function of Drosophila does not require a specific sequence. Without this sequence component, Drosophila telomeres most resemble DNA breaks and, thus, represent a simpler system for the study of telomere capping. I review recent progress in Drosophila telomere studies, and challenge the notion that Drosophila may not be a relevant model for the study of telomere maintenance.
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