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Updated: Jul 8, 2026
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A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
Published on: September 23, 2014
From medical images to multiple-biomarker microarrays
1Center for Devices and Radiological Health, FDA, 10903 New Hampshire Avenue, Building 62, Room 3126, Silver Spring, Maryland 20993-0002, USA.
Medical Physics
|January 17, 2008
Summary
Predicting the future of medical diagnostic technologies like CT and MRI has historically been challenging. Emerging diagnostic microarrays for multiple biomarkers face similar early-stage data limitations.
Area of Science:
- Medical Imaging
- Biomarker Discovery
- Diagnostic Technology
Background:
- Historical predictions in medical technology are often inaccurate.
- Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) faced significant early challenges.
- Emerging technologies often start with insufficient data.
Purpose of the Study:
- To review historical difficulties in predicting the future of diagnostic medical imaging (CT and MRI).
- To examine analogous challenges in diagnostic microarrays for multiple-biomarker problems.
- To highlight the 'ill-conditioned' nature of new diagnostic technologies.
Main Methods:
- Historical review of diagnostic imaging technologies.
- Comparative analysis of CT, MRI, and diagnostic microarrays.
- Examination of early-stage data limitations in emerging technologies.
Main Results:
- Both CT and MRI experienced initial difficulties due to insufficient data.
- Diagnostic microarrays for multiple biomarkers present similar 'ill-conditioned' problems.
- The development of new diagnostic tools is often hindered by initial data scarcity.
Conclusions:
- Predicting the trajectory of new diagnostic technologies is inherently difficult.
- Early-stage data limitations are a common characteristic of groundbreaking diagnostic tools.
- Understanding these historical parallels can inform the development of future diagnostic microarrays.
