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09:24
Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
Fluorine in medicinal chemistry
Sophie Purser1, Peter R Moore, Steve Swallow
1The Chemistry Research Laboratory, 12 Mansfield Road, Oxford, UK OX1 3TA.
Chemical Society Reviews
|January 17, 2008
Summary
Fluorinated compounds are vital in medicinal chemistry, offering key therapeutic leads. This review highlights famous fluorinated drugs, their mechanisms, and how fluorine impacts drug effectiveness.
Area of Science:
- Medicinal Chemistry
- Organic Chemistry
- Drug Discovery
Background:
- Fluorinated compounds have a significant history in medicinal chemistry.
- They continue to be crucial for developing new therapeutic agents.
- Fluorine substitution is a key strategy in drug design.
Purpose of the Study:
- To review prominent fluorinated drugs and their mechanisms of action.
- To elucidate the specific role and impact of fluorine in enhancing drug potency.
- To provide a tutorial overview for researchers in medicinal chemistry.
Main Methods:
- Literature review of established fluorinated drugs.
- Analysis of case studies detailing drug mechanisms.
- Discussion of structure-activity relationships concerning fluorine incorporation.
Main Results:
- Identified several renowned fluorinated drugs across various therapeutic areas.
- Demonstrated the diverse modes of action influenced by fluorine.
- Illustrated how fluorine substitution modulates pharmacokinetic and pharmacodynamic properties.
Conclusions:
- Fluorine substitution is a powerful tool for optimizing drug candidates.
- Fluorinated compounds represent a vital and expanding class of therapeutics.
- Understanding fluorine's impact is essential for future drug development.
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