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Updated: Jul 8, 2026
06:51
Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin
Published on: April 29, 2016
[Morpho-functional changes in hair during their renewal]
Morfologiia (Saint Petersburg, Russia)
|January 18, 2008
Summary
Human hair follicles (HF) develop from fetal skin and maintain a constant number throughout life. Their cyclic renewal involves distinct growth, regression, and resting phases regulated by complex cellular interactions.
Area of Science:
- Developmental biology
- Dermatology
- Cell biology
Context:
- Hair follicles (HF) originate from fetal epidermis during human embryogenesis, completing development by the sixth fetal month.
- The number of hair follicles remains constant throughout an individual's lifespan.
- Mature hair follicles are integral skin units exhibiting significant regenerative capabilities.
Purpose:
- To elucidate the developmental origins and lifelong constancy of human hair follicles.
- To detail the cyclic transformations of hair follicles, including anagen, catagen, and telogen phases.
- To explore the cellular and regulatory mechanisms governing hair renewal and the hair growth cycle.
Summary:
- Human hair follicles (HF) form from fetal epidermis and are established by month six of gestation, with their quantity remaining stable lifelong.
- Hair renewal is driven by the cyclic changes of HF, involving three distinct phases: anagen (growth), catagen (regression), and telogen (quiescence).
- The hair growth cycle is orchestrated by the interplay of various cell populations, encompassing proliferation, differentiation, migration, and apoptosis, with each stage governed by specific regulatory pathways.
Impact:
- Provides foundational knowledge on hair follicle development and homeostasis.
- Contributes to understanding skin regeneration and aging processes.
- Offers insights into the molecular and cellular basis of hair disorders and therapeutic interventions.
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