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Updated: Jul 8, 2026

Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle
Published on: August 30, 2021
[Bioamine-positive structures in the rat mesometrium and their changes in the estrous cycle]
Abstract:
The objective of this study was to demonstrate main bioamine-positive structures in rat mesometrium, to detect their spatial cooperations and to define their catecholamine, serotonin and histamin content during the sexual cycle. The study was performed in 120 female rats of reproductive age, which were divided into groups according to the stages of sexual cycle: early estrus, late estrus, metestrus, early diestrus, late diestrus, proestrus. By using the microspectrofluorometric histological methods, the following bioamine-positive structures were differentiated in rat mesometrium that were cooperated in space: sympathetic nerve fibers (containing catecholamines and serotonin), mast cells and macrophages (containing catecholamines, serotonin and histamine). Regular dynamics of individual bioamine indices was detected during the sexual cycle. The role of mesometrium in the system of uterine extraorganic bioamine supply is discussed.
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