Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacological advances in cannabinoid-based therapies for pancreatic cancer: preclinical efficacy of CCL-106 and its epimers.

ESMO gastrointestinal oncology·2025

Same author

Tracking Staphylococcus aureus in the intensive care unit using whole-genome sequencing.

The Journal of hospital infection·2019

Same author

Characterization of Agrobacterium vitis Strains Isolated from Feral Vitis riparia.

Plant disease·2019

Same author

Is there an association between airborne and surface microbes in the critical care environment?

The Journal of hospital infection·2018

Same author

The influence of aquaculture unit proximity on the pattern of Lepeophtheirus salmonis infection of anadromous Salmo trutta populations on the isle of Skye, Scotland.

Journal of fish biology·2018

Same author

Comparison of damage to live v. euthanized Atlantic salmon Salmo salar smolts from passage through an Archimedean screw turbine.

Journal of fish biology·2018

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 17, 2009

Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.

C E Adams¹, J C Yonchek, L Zheng

¹Medical Research, Veterans Affairs Medical Center, Denver, CO 80220, USA. cathy.adams@uchsc.edu

|January 18, 2008

Summary

Reduced alpha7 nicotinic receptors in the hippocampus impair auditory gating and increase neuron activity. This suggests a critical role for these receptors in hippocampal circuit function and sensory processing.

More Related Videos

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Related Experiment Videos

Last Updated: Jul 8, 2026

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 17, 2009

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Published on: February 26, 2012

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Area of Science:

Neuroscience
Neuropharmacology

Background:

The alpha7 nicotinic receptor is prevalent in the hippocampus.
It is believed to regulate the release of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter.
This regulation is hypothesized to be crucial for hippocampal auditory gating, which controls responses to repetitive auditory stimuli.

Purpose of the Study:

To investigate the role of hippocampal alpha7 nicotinic receptors in auditory gating.
To overcome the limitations of inter-strain comparisons by using genetically modified mice on a consistent background.

Main Methods:

Comparison of hippocampal alpha-bungarotoxin binding and auditory gating in C3H wild type and C3H alpha7 receptor null mutant heterozygous mice.
Assessment of CA3 pyramidal neuron responsivity.

Main Results:

C3H alpha7 heterozygous mice showed reduced hippocampal alpha7 receptor levels.
These mice also exhibited abnormal hippocampal auditory gating.
An overall increase in CA3 pyramidal neuron responsivity was noted in heterozygous mice compared to wild type.

Conclusions:

Decreasing hippocampal alpha7 nicotinic receptor density significantly alters hippocampal circuit function.
Alpha7 nicotinic receptors play a key role in modulating hippocampal inhibitory neurotransmission and sensory gating.