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Related Experiment Videos

Immunoreactive insulin levels in ankylosing spondylitis.

F J Jiménez-Balderas1, J L Solís, G Mintz

  • 1Depto. de Reumatología, Hosp. de Especialidades, Centro Médico Nacional, Instituto Mexicano del Seguro Social, D.F.

Archivos De Investigacion Medica
|April 1, 1991
PubMed
Summary

Ankylosing spondylitis (AS) patients with active inflammation showed higher insulin levels compared to controls. This suggests a potential link between AS and hyperinsulinism, requiring further investigation into its role in disease development.

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Area of Science:

  • Rheumatology
  • Endocrinology
  • Immunology

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease.
  • The relationship between AS and metabolic factors like insulin is not well understood.

Purpose of the Study:

  • To investigate serum glucose, insulin, and erythrocyte sedimentation rate (ESR) in AS patients.
  • To correlate these markers with disease activity.

Main Methods:

  • Measured serum glucose, immunoreactive insulin (AUC of glucose tolerance test), and ESR in 18 male AS patients and 7 male controls.
  • Correlated findings with clinical assessment of disease activity.

Main Results:

  • Active AS patients (n=14) had significantly higher insulin AUC (107.4 +/- 44.1 cm2) compared to controls (40.8 +/- 12.6 cm2, p<0.03).

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  • Inactive AS patients (n=4) showed no significant difference in insulin AUC compared to controls.
  • A direct correlation was found between ESR and serum insulin levels (r=0.47, p<0.05) in the whole group.

    • Conclusions:

    • Ankylosing spondylitis may be associated with hyperinsulinism.
    • The role of hyperinsulinism in the physiopathogenesis of AS warrants further research.