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Enzymatic manipulation of protecting groups: more than deprotection
1Institute of Biochemistry, Medical Faculty Martin-Luther-University, Halle, FRG.
Biomedica Biochimica Acta
|January 1, 1991
Abstract:
Recent developments in the enzymatic manipulation of protecting groups are reviewed. The application of enzymes opens new alternatives in the methodics of peptide synthesis. The following topics are dealt with: 1. New combinations of protecting groups 2. Simultaneous deprotections 3. Enzymatic regiospecificity versus chemical selectivity 4. Racemization control and enantioselective deprotection 5. N- and O-glycosylated amino acid and peptide derivatives.