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Chymotrypsin-catalyzed fragment coupling synthesis of GnRH-analogs
A Hänsicke1, E Krause, M Bienert
1Berlin-Chemie AG, Berlin.
Biomedica Biochimica Acta
|January 1, 1991
Abstract:
D-Xaa6-GnRH analogs (Xaa: Ala, Nal1), Phe, Ser(tBu), Trp) were prepared by chymotrypsin catalyzed 3 + 7 fragment coupling synthesis with conversion rates of the amino component in the range from 90.3 to 97.4%. For D-Phe6-GnRH the method was scaled up to production level.