Related Experiment Video
Updated: Jul 8, 2026
06:08
Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
Rhinorrhea not responding to nasal corticosteroids.
Parag N Patel1, Benjamin Oyefara, Robert Aarstad
1Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA.
Allergy and Asthma Proceedings
|January 19, 2008
Summary
Cerebrospinal fluid (CSF) rhinorrhea, a rare cause of persistent runny nose, was diagnosed after a facial injury. Early recognition and surgical repair prevented serious complications.
Area of Science:
- Neurology
- Otolaryngology
- Radiology
Background:
- Persistent rhinorrhea can mimic allergic rhinitis, delaying diagnosis of underlying conditions.
- Facial trauma can lead to cerebrospinal fluid (CSF) leaks, a potentially serious condition.
Observation:
- A patient with allergic rhinitis presented with persistent rhinorrhea post-facial trauma.
- Initial emergency department visit following trauma noted several concerning symptoms but lacked radiologic evaluation.
- Clinic examination revealed clear nasal discharge, prompting suspicion of CSF rhinorrhea.
Findings:
- Beta-2-transferrin test confirmed cerebrospinal fluid (CSF) leak.
- High-resolution sinus CT identified a cribriform plate dehiscence and fluid in the sphenoid sinus.
- Nasal endoscopy revealed a dural tear and CSF leak from the cribriform plate.
Implications:
- Considering CSF rhinorrhea in the differential diagnosis of persistent rhinitis is crucial for timely intervention.
- Prompt diagnosis and surgical management of CSF leaks prevent complications like meningitis.
- This case highlights the importance of thorough evaluation after head trauma, even with initial discharge from emergency care.
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