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WAO - ARIA consensus on chronic cough: Executive summary.
Philip W Rouadi1, Samar A Idriss1, Jean Bousquet2,3,4
1Department of Otolaryngology, Dar Al Shifa Hospital, Hawally, Kuwait.
The World Allergy Organization Journal
|March 17, 2025
Summary
Chronic cough is a complex condition impacting quality of life. This summary reviews its pathophysiology, phenotypes, and management for clinicians, aiming to improve patient outcomes through increased awareness.
Area of Science:
- Pulmonology
- Neurology
- Pharmacology
Background:
- Chronic cough significantly impacts patient quality of life.
- Mechanistic pathways in complex cough phenotypes remain unclear.
- Hypersensitive cough reflex and specific receptors (transient receptor potential channels, P2X receptors) are implicated in cough pathways.
Purpose of the Study:
- To provide clinicians with a succinct summary of chronic cough pathophysiology, clinical phenotypes, and management.
- To serve as a primer for primary care physicians and cough specialty care providers.
- To increase awareness of chronic cough to improve patient management outcomes.
Main Methods:
- Review of updated experimental and clinical data on chronic cough.
- Inclusion of a multidisciplinary care pathway approach.
- Synthesis of information for clinical application.
Main Results:
- Elucidation of mechanistic pathways in chronic cough is ongoing.
- Evidence points to a hypersensitive cough reflex.
- Transient receptor potential channels and P2X receptors are key neuronal players.
Conclusions:
- Increased awareness among primary care physicians is crucial for better chronic cough management.
- Understanding pathophysiology and phenotypes aids in effective treatment strategies.
- A multidisciplinary approach is recommended for managing chronic cough.
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