Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

2D-Echocardiographic Estimation of Right Ventricular Volumes Using a Previously Validated Geometric Model Is Associated With Outcomes After Transcatheter Tricuspid Interventions.

Echocardiography (Mount Kisco, N.Y.)·2026
Same author

Serial sST2 dynamics after transcatheter tricuspid valve intervention: a candidate biomarker of biological response.

Biomarkers in medicine·2026
Same author

Alpha2 agonists for sedation to produce better outcomes for adults with critical illness: a synopsis of the A2B RCT with cost-effectiveness and process evaluation.

Health technology assessment (Winchester, England)·2026
Same author

Prognostic Performance of a Modified TRI-SCORE Incorporating RV-PA Uncoupling After Transcatheter Tricuspid Valve Interventions.

Journal of cardiovascular development and disease·2026
Same author

Comparative prognostic performance of risk scores for 12-month mortality and rehospitalization after transcatheter tricuspid valve intervention.

Annals of cardiothoracic surgery·2026
Same author

Clinical outcomes of hemostatic interventions in patients with traumatic injury: A systematic review of randomized controlled trials.

The journal of trauma and acute care surgery·2026

Related Experiment Video

Updated: Jul 8, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

N-Acetylcysteine does not artifactually lower plasma creatinine concentration.

Michael Haase1, Anja Haase-Fielitz, Sujiva Ratnaike

  • 1Director of Intensive Care Research, Austin Hospital, University of Melbourne, 3084 Heidelberg, Victoria, Australia.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 19, 2008
PubMed
Summary

N-acetylcysteine (NAC) does not appear to artificially lower creatinine levels, a key marker for kidney function. This study found no significant differences in creatinine or estimated GFR between NAC and placebo groups in cardiac surgery patients.

More Related Videos

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

Related Experiment Videos

Last Updated: Jul 8, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • N-acetylcysteine (NAC) is studied for contrast media-induced nephropathy.
  • Creatinine is the standard marker for renal function in these trials.
  • Concerns exist that NAC may lower plasma creatinine independent of actual kidney function.

Purpose of the Study:

  • To investigate whether N-acetylcysteine (NAC) artifactually lowers plasma creatinine levels.
  • To assess the impact of NAC on renal function markers beyond creatinine.

Main Methods:

  • 110 cardiac surgical patients received either NAC or placebo peri-operatively.
  • Compared plasma creatinine, cystatin C, urea, creatinine/cystatin C ratio, and estimated GFR.
  • Measured urinary creatinine excretion at 24 hours.

Main Results:

  • No significant difference in the plasma creatinine/cystatin C ratio between NAC and placebo groups at baseline, 24 hours, or 72 hours.
  • Urinary creatinine excretion was also similar between groups.
  • The study found no evidence of NAC artifactually lowering creatinine measurements.

Conclusions:

  • N-acetylcysteine (NAC) does not appear to artifactually lower creatinine levels as measured by the Jaffé method.
  • These findings suggest creatinine is a reliable marker for renal function in patients receiving NAC.
  • Supports the continued use of creatinine in evaluating NAC's efficacy in preventing nephropathy.