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Updated: Jul 8, 2026

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
Published on: August 2, 2018
The magic of the hypoxia-signaling cascade
E Benizri1, A Ginouvès, E Berra
1CNRS UMR 6543, University of Nice, Centre Antoine Lacassagne, 33 Avenue Valombrose, Nice, France.
Abstract:
All organisms respond to changes in their environment by activating complex signaling cascades. The "hypoxia-signaling cascade" is activated in response to low oxygen availability and this activation is central to maintaining oxygen homeostasis and hence to survival. By regulating the transcriptional complex hypoxia-inducible factor, hypoxia is associated with several physiopathological processes. Several strategies, based on the targeting of the hypoxia-signaling cascade, have been developed to treat these pathologies. Our review summarize different aspects of the hypoxic pathway.
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