Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extending the prognostic value of red cell distribution width to nodal T follicular helper cell lymphoma.

Leukemia & lymphoma·2026
Same author

Impact of disease status and general condition on changes in physical function before and after allogeneic hematopoietic stem cell transplantation.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Artificial intelligence in food safety.

NPJ science of food·2026
Same author

Treatment-specific differences in soluble B-cell maturation antigen levels at minimum residual disease negativity in multiple myeloma.

British journal of haematology·2026
Same author

Gilteritinib response in acute myeloid leukemia harboring a rare FLT3 juxtamembrane domain mutation with subsequent clonal evolution.

Annals of hematology·2026
Same author

Rethinking Group B Streptococcus: The Rise of Sequence Type 283 as a Foodborne Zoonotic Pathogen.

Comprehensive reviews in food science and food safety·2026

Related Experiment Video

Updated: Jul 8, 2026

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
11:10

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

[Primary amyloidosis associated with IgD-lambda M-proteinemia].

Shunichi Kimura1, Ryota Iwatsuka, Takatoshi Aoki

  • 1Department of Hematology and Oncology, Kameda Medical Center.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|January 22, 2008
PubMed
Summary
This summary is machine-generated.

This case report details primary AL amyloidosis linked to IgD monoclonal gammopathy of undetermined significance, a rare condition. It highlights diagnostic challenges and the importance of considering amyloidosis in renal failure cases.

More Related Videos

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Related Experiment Videos

Last Updated: Jul 8, 2026

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
11:10

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Area of Science:

  • Hematology
  • Oncology
  • Nephrology

Background:

  • Primary AL amyloidosis is a plasma cell disorder characterized by amyloid deposition.
  • Monoclonal gammopathies of undetermined significance (MGUS) are common, but IgD MGUS is rare.
  • Renal failure is a common complication of AL amyloidosis.

Observation:

  • A 73-year-old man presented with renal failure and Bence Jones proteinuria, initially suspected of multiple myeloma.
  • Serum electrophoresis identified an IgD lambda monoclonal protein, but bone marrow biopsy showed no plasma cell proliferation.
  • Physical examination revealed macroglossia and facial ecchymosis, prompting suspicion of amyloidosis.

Findings:

  • Skin biopsy confirmed extensive amyloid deposition, positive with Congo red staining.
  • A diagnosis of primary AL amyloidosis associated with IgD monoclonal gammopathy of undetermined significance was established.
  • The patient developed end-stage renal disease requiring hemodialysis.

Implications:

  • This is the first reported case of primary AL amyloidosis associated with IgD monoclonal gammopathy of undetermined significance.
  • The case underscores the diagnostic complexity of AL amyloidosis, especially with rare monoclonal gammopathies.
  • Early recognition and diagnosis are crucial for managing AL amyloidosis and its complications, including renal failure.