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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...

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Related Experiment Videos

Tinea faciei: a report on four cases.

A Khaled1, O Chtourou, F Zeglaoui

  • 1Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia. aida.khaled@rns.tn

Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica
|January 22, 2008
PubMed
Summary

This study reports four female cases of tinea faciei, a fungal infection of the face. Early diagnosis and appropriate antifungal treatment, like griseofulvin and terbinafine, are crucial for effective recovery.

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Area of Science:

  • Dermatology
  • Mycology
  • Infectious Diseases

Background:

  • Tinea faciei, a fungal infection of the face, can present with varied clinical appearances.
  • Misdiagnosis, particularly as eczema, can lead to inappropriate treatments and disease exacerbation.

Observation:

  • Four female patients with tinea faciei were observed at Charles Nicolle Hospital, Tunis.
  • Lesion duration ranged from one month to one year.
  • Trichophyton rubrum was identified in three out of four patients via mycological examination.

Findings:

  • Three patients achieved complete recovery within one month using a combination of oral griseofulvin and topical terbinafine.
  • One patient, initially misdiagnosed with eczema and treated with topical corticosteroids, experienced disease exacerbation.
  • Pregnancy necessitated topical-only treatment for one patient.

Implications:

  • Erythematous facial lesions warrant mycological investigation to rule out fungal infections like tinea faciei.
  • Prompt and accurate diagnosis is essential to prevent treatment delays and complications.
  • Combination antifungal therapy demonstrates efficacy in treating tinea faciei.