Related Experiment Video
Updated: Jul 8, 2026
06:55
Ileectomy-induced Bile Overaccumulation in Mouse Intestine
Published on: August 21, 2017
Body composition and metabolic changes associated with massive intestinal resection in mice
Niramol Tantemsapya1, Jareen Meinzner-Derr, Christopher R Erwin
1Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Journal of Pediatric Surgery
|January 22, 2008
Summary
Massive small bowel resection (SBR) in mice led to reduced metabolism and energy expenditure. Body fat was restored, but lean mass and weight remained lower during adaptation without parenteral nutrition.
Area of Science:
- Gastroenterology
- Metabolic research
- Surgical adaptation
Background:
- The metabolic and body composition changes following extensive intestinal loss are not well understood.
- This study investigates these alterations in a mouse model of small bowel resection (SBR).
Purpose of the Study:
- To determine changes in body composition and metabolism after massive small bowel resection (SBR).
Main Methods:
- Male C57/Bl6 mice underwent either 50% small bowel resection (SBR) or a sham operation.
- Indirect calorimetry and nuclear magnetic resonance were used to measure metabolism and body composition post-operation.
Main Results:
- SBR mice exhibited lower energy expenditure, oxygen consumption, and carbon dioxide production compared to sham controls.
- While body fat was replenished by two weeks post-SBR, body weight and lean mass remained significantly lower.
Conclusions:
- Adaptation to massive SBR without parenteral nutrition results in reduced energy metabolism and preferential fat store replenishment over lean mass.
- Further research is needed to explore growth factors for enhancing adaptation in SBR.
