Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

Inborn Errors of Metabolism

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...

Pleiotropy

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

Nephrotic Syndrome III : Nursing Management

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Smooth Endoplasmic Reticulum

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Medical therapy in mild autonomous cortisol secretion.

Journal of the Endocrine Society·2026

Same author

Impact of Osilodrostat on Health-Related Quality of Life in Cushing's Disease: Analysis of Patient-Reported Outcomes From the Phase III LINC 3 and LINC 4 Clinical Trials.

Clinical endocrinology·2026

Same author

Multimodal management of hormonal and oncological progression in PTHrP-secreting pancreatic neuroendocrine tumours.

Endocrine oncology (Bristol, England)·2026

Same author

Update and Practical Recommendations for the Use of Medical Treatment of Cushing Syndrome.

Endocrine reviews·2026

Same author

Controlling cortisol excess and comorbidities in Cushing's syndrome with osilodrostat.

Pituitary·2025

Same author

Rare Causes of Hypoglycemia-Lessons from Case Reports.

JCEM case reports·2025

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Nelson's Syndrome.

Alia Munir¹, John Newell-Price

¹Academic Unit of Diabetes, Endocrinology & Metabolism, School of Medicine and Biomedical Science, The University of Sheffield, Sheffield, UK.

Arquivos Brasileiros De Endocrinologia E Metabologia

|January 23, 2008

Summary

Nelson's syndrome, a complication of Cushing's disease treatment, involves aggressive pituitary tumors. Management is challenging due to varying definitions and disease heterogeneity.

Area of Science:

Endocrinology
Oncology
Neurosurgery

Background:

Nelson's syndrome is a severe complication following bilateral adrenalectomy for Cushing's disease.
Pituitary tumors in Nelson's syndrome can be locally aggressive and potentially fatal.
Laparoscopic bilateral adrenal surgery for Cushing's disease is increasingly used, highlighting the relevance of Nelson's syndrome.

Purpose of the Study:

To review the clinical and epidemiological features of Nelson's syndrome.
To discuss current treatment modalities for Nelson's syndrome.
To address the heterogeneity and evolving definition of Nelson's syndrome.

Main Methods:

Literature review of clinical and epidemiological data.
Analysis of treatment strategies for Nelson's syndrome.

More Related Videos

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Related Experiment Videos

Last Updated: Jul 8, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Discussion of diagnostic criteria and disease evolution.

Main Results:

Nelson's syndrome presents with significant heterogeneity in clinical presentation and definition.
Pituitary tumor growth is a major concern, with potential for mortality.
Lack of consensus on diagnostic criteria complicates research and management.

Conclusions:

Nelson's syndrome management remains challenging due to its aggressive pituitary tumors and varying definitions.
The modern understanding of Nelson's syndrome may differ from historical descriptions.
Further research is needed to establish clear diagnostic criteria and optimize treatment strategies.