Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin involvement in oxidative processes.

O Ianăş1, R Olinescu, I Bădescu

  • 1C. I. Parhon Institute of Endocrinology, Bucharest, Romania.

Endocrinologie
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CORRELATIONS BETWEEN POLYMORPHISMS OF ESTROGEN 1, VITAMIN D RECEPTORS AND HORMONAL PROFILE IN INFERTILE MEN.

Acta endocrinologica (Bucharest, Romania : 2005)·2019
Same author

Dynamic of oxidative and nitrosative stress markers during the convalescent period of stroke patients undergoing rehabilitation.

Annals of clinical biochemistry·2011
Same author

Oxygen, a paradoxical element?

Romanian journal of internal medicine = Revue roumaine de medecine interne·2009
Same author

Significant modification of lipid metabolism in aged persons following the treatment with a nutritive supplement containing embryonary peptides--preliminary results.

Romanian journal of internal medicine = Revue roumaine de medecine interne·2006
Same author

The levels of bilirubin may be related to an inflammatory condition in patients with coronary heart disease.

Romanian journal of internal medicine = Revue roumaine de medecine interne·2004
Same author

The formation of oxidative stress condition in the experimental chemically induced hepatotoxicity.

Roczniki Akademii Medycznej w Bialymstoku (1995)·2003
Same journal

[Bioethics in Romania. Science is a challenge, bioethics is a response].

Endocrinologie·1991
Same journal

Changes in the iodine content of vegetables following the Chernobyl accident.

Endocrinologie·1991
Same journal

Epidemiological surveillance of iodine deficiency in Romania by urinary iodine determinations in children aged 6-16 years from 30 counties.

Endocrinologie·1991
Same journal

Cardiac disturbances in thyrotoxicosis: diagnosis, incidence, clinical features and management.

Endocrinologie·1991
Same journal

Influence of sex and glucocorticoid hormones on 3H cholesterol uptake in the aortic wall and 3H adrenaline in the brain.

Endocrinologie·1991
Same journal

Cardiothyreosis.

Endocrinologie·1991
See all related articles

Melatonin exhibits a dual role in oxidative processes, acting as a pro-oxidant at low concentrations and an antioxidant at higher levels. This effect is modulated by peroxide concentrations and the presence of substances like tryptophan.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Oxidative Stress Research

Background:

  • The pineal gland produces melatonin, a hormone that regulates adaptation to light-dark cycles.
  • Melatonin's role in oxidative processes is suggested by its response to environmental light variations.
  • Understanding melatonin's redox capacity is crucial for its physiological implications.

Purpose of the Study:

  • To investigate the in vitro redox properties of melatonin.
  • To determine the dose-dependent pro-oxidative and antioxidative effects of melatonin.
  • To explore the influence of peroxide concentration and other substances on melatonin's redox activity.

Main Methods:

  • Utilized a luminol and hydrogen peroxide chemiluminescence system to generate free radicals.

Related Experiment Videos

  • Incubated melatonin in varying concentrations (0.08-0.5 microM/ml) with the chemiluminescence system.
  • Assessed melatonin's effects in the presence of hypothalamic homogenate and tryptophan.

    • Main Results:

    • Melatonin demonstrated a pro-oxidative effect at concentrations below 0.25 microM/ml and an antioxidative effect above this threshold.
    • Melatonin's antioxidative properties increased with higher peroxide concentrations (below 8 mM/ml).
    • In the presence of hypothalamic homogenate or tryptophan, melatonin exhibited dose-dependent antioxidative effects at low concentrations and pro-oxidative effects at higher doses.

    Conclusions:

    • Melatonin acts as a dose-dependent modulator of oxidative processes.
    • Its redox capacity is influenced by environmental factors such as peroxide levels.
    • Melatonin's dual pro-oxidative and antioxidative functions highlight its complex role in cellular redox homeostasis.