Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 8, 2026

DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
10:38

DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens

Published on: February 1, 2020

[Lessons from Guam ALS/PDC study].

Hirano Asao1

  • 1Division of Neuropathology, Montefiore Medical Center, Bronx, New York 10467-2490, USA.

Rinsho Shinkeigaku = Clinical Neurology
|January 24, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Decision Making: P-value Method01:09

Decision Making: P-value Method

The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim  is also stated. These statements can act as null and alternative hypotheses:  a null hypothesis would be a neutral statement while the alternative hypothesis can have a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

[Utility of acute-phase cerebral blood flow single photon emission computed tomography (SPECT) for evaluating the pathophysiology of Bickerstaff brainstem encephalitis with decorticate posturing].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Successful treatment with rituximab in unilateral relapsing primary CNS vasculitis: a ‍case report].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Clinical management of headache comorbid with functional neurological disorder].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Transient myoclonic state with asterixis related to COVID-19].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Let's present at a regional meeting].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Editor's Note].

Rinsho shinkeigaku = Clinical neurology·2026
See all related articles

Amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) on Guam showed a decline, possibly due to environmental and lifestyle changes. The etiology of these neurodegenerative diseases remains unknown, with no new treatments available.

Area of Science:

  • Neuroscience
  • Neuropathology
  • Epidemiology

Context:

  • Amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) were historically prevalent in Guam's native population.
  • These neurodegenerative conditions presented unique histological findings, including abundant neurofibrillary tangles without senile plaques.

Purpose:

  • To review advances in age-associated neurodegenerative diseases since the initial Guam studies.
  • To discuss clinical and neuropathological parallels and divergences with other neurodegenerative disorders.
  • To examine the epidemiological shift in Guam ALS/PDC incidence and potential environmental links.

Summary:

  • Guam ALS/PDC shares features with classic ALS and Parkinson's disease, but with distinct tau pathology.
  • The decline in Guam ALS/PDC incidence suggests environmental or lifestyle factors may play a role.

Related Experiment Videos

Last Updated: Jul 8, 2026

DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
10:38

DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens

Published on: February 1, 2020

  • Research into familial ALS and tauopathies has advanced, though Guam ALS/PDC etiology remains elusive.

    • Impact:

    • Highlights the importance of environmental factors in neurodegenerative disease etiology.
    • Provides insights into the complex relationship between tau pathology, parkinsonism, and dementia.
    • Underscores the need for continued research into rare neurodegenerative conditions and their potential triggers.