Related Experiment Videos
[Post-vaccination reactions and complications of pertussis, diphtheria and tetanus vaccines]
B Vuković1, Z Seguljev, V Nikolić
1Institut za zdravstvenu zastitu, Medicinski fakultet, Novi Sad.
Insights
Most childhood immunizations cause mild reactions, often at the injection site. Allergic reactions were common, with pertussis antigens frequently triggering antibodies in children who received the Di-Te-Per vaccine.
Area of Science:
- Pediatrics
- Immunology
- Vaccinology
Context:
- Analysis of postvaccinal reactions and complications in 80 children.
- Evaluation of sensibilizing antibodies to vaccine components.
Purpose:
- To analyze clinical manifestations of postvaccinal reactions and complications.
- To identify the prevalence of allergic reactions and specific antibodies.
Summary:
- Most children (80) experienced mild reactions to Di-Te-Per, Di-Te, or Te vaccines, with site-specific reactions more common with Di-Te and Te vaccines.
- Indirect basophil degranulation tests indicated 50% of reactions were allergic.
- Sensitizing antibodies to pertussis antigen were significantly more frequent than to diphtheria, tetanus, or vaccine additives.
Impact:
- Highlights the potential for allergic reactions to childhood vaccines.
- Identifies pertussis antigen as a common trigger for sensitizing antibodies.
- Informs vaccine safety monitoring and understanding of post-immunization responses.
Abstract:
Clinical manifestation of postvaccinal reactions and complications and the presence of sensibilizating antibodies to certain components of the applied vaccines was analyzed in 80 children immunized by Di-Te-Per, Di-Te or Te vaccine. Most children showed a mild reaction; concerning statistical significance it was most frequently limited to the site of the vaccine application if the immunization was performed by Di-Te and Te vaccines, as compared to the immunization by Di-Te-Per vaccine. Indirect basophil degranulation test revealed that 50% of the analyzed reactions were of allergic origin. Sensibilizating antibodies to pertussis antigen are statistically significantly more frequent than to other vaccinal antigens (diphtheria and tetanus toxoids) and additives contained in the vaccines (methiolate, sodium benzoate).