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Updated: Jul 8, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
Review on diagnosis and treatment of focal segmental glomerulosclerosis
J K J Deegens1, E J Steenbergen, J F M Wetzels
1Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. j.deegens@nier.umcn.nl
Abstract:
Focal segmental glomerulosclerosis (FSGS) is one the most important causes of the nephrotic syndrome in adult patients. FSGS is not a disease entity. The identification of underlying causes of FSGS (secondary FSGS) has increased our insight into the pathogenesis of FSGS. Moreover, differentiating between primary (idiopathic) and secondary forms of FSGS is important to allow appropriate treatment. Recently a new pathological classification of FSGS was proposed, expanding FSGS to include nonsclerotic lesions. In this review we discuss the current diagnostic and therapeutic options in patients with FSGS.
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