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Persistent default-mode network connectivity during light sedation.

Michael D Greicius1, Vesa Kiviniemi, Osmo Tervonen

  • 1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305-5235, USA. greicius@stanford.edu

Human Brain Mapping
|January 26, 2008
PubMed
Summary
This summary is machine-generated.

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The default-mode network (DMN) remains functionally connected during sedation, but connectivity in the posterior cingulate cortex significantly decreases. This focal reduction may indicate reduced consciousness.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • The default-mode network (DMN) is active during rest and involved in internal mentation.
  • Its role in consciousness and memory processing is under investigation.
  • Reduced consciousness states offer a unique window to study DMN function.

Purpose of the Study:

  • To investigate default-mode network (DMN) functional connectivity during conscious sedation.
  • To identify brain regions whose connectivity is altered by reduced consciousness.

Main Methods:

  • Functional connectivity MRI was used to compare DMN activity during rest and conscious sedation (midazolam).
  • Subjects underwent fMRI scans in both states.
  • Connectivity differences were analyzed, focusing on the posterior cingulate cortex.

Related Experiment Videos

Main Results:

  • The DMN exhibited functional connectivity during both rest and conscious sedation.
  • A significant reduction in functional connectivity was observed in the posterior cingulate cortex during conscious sedation.
  • Low-frequency oscillations within the DMN persisted despite reduced consciousness.

Conclusions:

  • The default-mode network (DMN) maintains functional connectivity even with decreased consciousness.
  • Focal reductions in DMN connectivity, particularly in the posterior cingulate cortex, may serve as a neural correlate of reduced consciousness.
  • This suggests specific DMN regions are sensitive to alterations in conscious state.