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Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
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Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

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[INFLAMMATION AND HEMOCOAGULATION].

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Related Experiment Video

Updated: Jul 8, 2026

Ferric Chloride-induced Murine Thrombosis Models
10:37

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

[Antiphospholipid syndrome: modern problems].

I N Bokarev, A V Arshinov, A L Mel'nikov

    Klinicheskaia Meditsina
    |January 29, 2008
    PubMed
    Summary

    This article traces the evolution of antiphospholipid syndrome (AFS) diagnosis, clarifying current criteria and exploring its pathogenesis and links to inherited clotting disorders.

    Area of Science:

    • Medical Science
    • Pathology
    • Immunology

    Context:

    • Antiphospholipid syndrome (AFS) diagnosis has evolved significantly.
    • Understanding its clinical manifestations and diagnostic markers is crucial for patient care.

    Purpose:

    • To provide a historical overview of antiphospholipid syndrome (AFS) concept development.
    • To clarify modern diagnostic criteria, pathogenetic mechanisms, and associations with thrombophilia.
    • To discuss unresolved clinical issues and propose refined diagnostic criteria for AFS.

    Summary:

    • The article reviews the historical formation and conceptual development of antiphospholipid syndrome (AFS).
    • It details the evolution of clinical symptoms and laboratory tests for AFS diagnosis.
    • Modern interpretations, pathogenetic theories, links to congenital thrombophilias, and diagnostic criteria are discussed.

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    Published on: November 29, 2024

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    Last Updated: Jul 8, 2026

    Ferric Chloride-induced Murine Thrombosis Models
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    Published on: September 5, 2016

    Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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    Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

    Published on: November 29, 2024

    Impact:

    • Refines the understanding of antiphospholipid syndrome (AFS) for clinicians.
    • Aids in accurate diagnosis and management of AFS.
    • Contributes to the ongoing research into AFS pathogenesis and treatment.