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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

[Renal dysfunction and anemia in old patients with diastolic cardiac failure]

A M Shutov, L Iu Tarmonova

    Terapevticheskii Arkhiv
    |January 29, 2008
    PubMed

    Insights

    Anemia and reduced kidney function in elderly patients with chronic diastolic cardiac failure (CDCF) worsen symptoms and impact left ventricular diastolic filling. Lower glomerular filtration rate (GFR) prolongs relaxation, while lower hemoglobin increases early filling velocity.

    Area of Science:

    • Cardiology
    • Nephrology
    • Geriatrics

    Context:

    • Chronic diastolic cardiac failure (CDCF) affects elderly individuals.
    • Renal insufficiency and anemia are common comorbidities in this population.
    • Diastolic dysfunction significantly impacts cardiac function and patient outcomes.

    Purpose:

    • To investigate the influence of renal functional insufficiency and anemia on clinical presentation and left ventricular diastolic filling in elderly patients with CDCF.
    • To determine the relationship between glomerular filtration rate (GFR), hemoglobin levels, and diastolic function parameters.

    Summary:

    • The study examined 116 elderly patients with CDCF, assessing renal function (GFR) and anemia.
    • A significant percentage of patients had reduced GFR (36.2%) and anemia (28.4%), with a notable overlap (18.1%).
    • Results indicated a direct correlation between hemoglobin and GFR, and that reduced GFR prolonged isovolumic relaxation time, while lower hemoglobin increased early diastolic filling velocity.

    Impact:

    • Findings highlight the critical role of renal function and anemia in modulating diastolic function in elderly CDCF patients.
    • This underscores the importance of managing these comorbidities to improve clinical outcomes.
    • The study provides insights into the complex interplay of factors affecting diastolic filling in this vulnerable group.
    Abstract

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