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Glycomics: towards bioinformatic approaches to understanding glycosylation

Lara K Mahal1

  • 1Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station, A5300, Austin, TX 78712-0265, USA. lmahal@cm.utexas.edu

Anti-Cancer Agents in Medicinal Chemistry
|January 29, 2008
PubMed

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Oligosaccharide Assembly

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Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
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Glycosaminoglycans

Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
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