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Related Experiment Videos

Current progress with primate embryonic stem cells.

James A Byrne1, Shoukhrat M Mitalipov, Don P Wolf

  • 1Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR, USA. byrnej@ohsu.edu

Current Stem Cell Research & Therapy
|January 29, 2008
PubMed
Summary
This summary is machine-generated.

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Preface.

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Embryonic stem cells (ESCs) hold promise for treating degenerative diseases. Rhesus macaques are crucial for pre-clinical trials evaluating ESC therapies, focusing on safety and efficacy before human application.

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Primate models

Background:

  • Embryonic stem cells (ESCs) possess indefinite proliferation and pluripotency.
  • ESC differentiation offers potential for treating degenerative diseases.
  • Safety concerns like apoptosis and tumor formation necessitate careful pre-clinical evaluation.

Purpose of the Study:

  • To review the genetic and epigenetic integrity of primate ESCs.
  • To examine the current use of primate ESCs in pre-clinical trials.
  • To discuss the potential of generating isogenic ESC-derived cells via somatic cell nuclear transfer.

Main Methods:

  • Evaluation of genetic and epigenetic integrity in primate ESCs.
  • Review of pre-clinical trial data for ESC-based therapies.

Related Experiment Videos

  • Exploration of somatic cell nuclear transfer for isogenic cell production.

    • Main Results:

    • Primate ESC lines are increasingly available for research.
    • Rhesus macaques serve as an ideal model for ESC therapy assessment.
    • Progress is being made in understanding ESC integrity and pre-clinical applications.

    Conclusions:

    • Primate ESCs are vital for advancing regenerative medicine.
    • Careful pre-clinical evaluation in models like rhesus macaques is essential.
    • Isogenic cell generation holds promise for safer ESC therapies.