Related Experiment Video
Updated: Jul 8, 2026

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
Published on: December 23, 2011
Stem cell migration: a quintessential stepping stone to successful therapy
Corinna Weidt1, Bernd Niggemann, Benjamin Kasenda
1Department of Medicine, Hematology and Oncology, University Hospital Muenster, Albert-Schweitzer-Strasse 33, D-48129 Muenster, Germany. cweidt@web.de
Abstract:
Migration is an innate and fundamental cellular function that enables hematopoietic stem cells (HSCs) and endothelial progenitors (EPCs) to leave the bone marrow, relocate to distant tissue, and to return to the bone marrow. An increasing number of studies demonstrate the widening scope of the therapeutic potential of both HSCs and endothelial cells. Therapeutic success however not only relies upon their ability to repair damaged tissue, but is also fundamentally dependent on the migration to these areas. Extensive in vivo and in vitro research efforts have shown that the most significant effects seen on HSC migration are initiated by the chemokine SDF-1alpha. In this review we will elucidate the many cellular and systemic factors of HSC and EPC cell migration and their modi operandi.
Related Concept Videos
Cell Migration
Cell Migration
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture
Mesenchymal Stem Cells
Multipotency of Hematopoietic Stem Cells

