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CD34+ fibrocytes: morphology, histogenesis and function.

Peter J Barth1, Christina C Westhoff

  • 1Institute of Pathology University Hospital Giessen and Marburg GmbH, Location Marburg, Medical Faculty of Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany. barthp@mailer.uni-marburg.de

Current Stem Cell Research & Therapy
|January 29, 2008
PubMed
Summary
This summary is machine-generated.

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Preface.

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Resident CD34(+) fibrocytes, derived from monocytes, are vital for tissue repair and immune response. Their transformation into myofibroblasts in cancer may impair immune surveillance, aiding tumor invasion.

Area of Science:

  • Immunology
  • Cell Biology
  • Oncology

Background:

  • CD34(+) fibrocytes are abundant in human connective tissue and originate from circulating CD14(+) monocytes.
  • These fibrocytes perform crucial roles including wound healing, antigen presentation, and cytokine secretion.
  • They are implicated in connective tissue diseases, pulmonary fibrosis, and tumor-associated stromal remodeling.

Purpose of the Study:

  • To investigate the role of CD34(+) fibrocytes in connective tissue and their phenotypic changes in invasive carcinomas.
  • To understand how stromal remodeling impacts tumor invasion and immune escape.

Main Methods:

  • Analysis of CD34(+) and alpha-SMA expression in stromal cells.
  • Characterization of fibrocytes and myofibroblasts in the tumor microenvironment.

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Main Results:

  • Invasive carcinomas induce stromal remodeling, characterized by loss of CD34(+) expression and gain of alpha-SMA expression.
  • This results in a phenotype shift from CD34(+) fibrocytes to alpha-SMA positive myofibroblasts.
  • Reduced antigen-presenting CD34(+) fibrocytes may facilitate tumor cells evading host immune control.

Conclusions:

  • The transformation of CD34(+) fibrocytes to myofibroblasts is a key event in tumor-associated stromal remodeling.
  • This phenotypic switch may be essential for local tumor invasion and systemic dissemination.
  • A decrease in functional CD34(+) fibrocytes could compromise anti-tumor immunity.