Related Experiment Video
Updated: Jul 7, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
Published on: July 14, 2021
Surgical methods to reverse left ventricular remodeling
Michele De Bonis1, Ottavio Alfieri
1Department of Cardiac Surgery, San Raffaele University Hospital, Via Olgettina 60, 20132 Milano, Italy. michele.debonis@hsr.it
Insights
Heart transplantation is limited for end-stage dilated cardiomyopathy. This review covers surgical methods to reverse ventricular remodeling, improving heart failure symptoms and survival.
Area of Science:
- Cardiology
- Cardiac Surgery
- Heart Failure Research
Background:
- Heart transplantation is the primary treatment for end-stage dilated cardiomyopathy.
- Limited donor organs and contraindications restrict transplantation's impact on heart failure.
- Ventricular remodeling exacerbates systolic heart failure, impacting patient outcomes.
Purpose of the Study:
- To review surgical interventions for reversing cardiac remodeling in systolic heart failure.
- To discuss the indications, outcomes, and limitations of current surgical methods.
- To provide insights into managing heart failure beyond transplantation.
Main Methods:
- Literature review of conventional surgical procedures for cardiac remodeling.
- Analysis of studies focusing on ventricular remodeling reversal.
- Synthesis of data on surgical indications, results, and limitations.
Main Results:
- Conventional surgical procedures offer alternatives to heart transplantation.
- These methods aim to mitigate adverse ventricular remodeling.
- Surgical interventions can improve symptoms and survival in heart failure patients.
Conclusions:
- Surgical approaches are crucial for managing heart failure when transplantation is not feasible.
- Understanding the indications and limitations of these surgeries is vital for patient care.
- Further research into optimizing surgical strategies for cardiac remodeling is warranted.
Abstract:
Heart transplantation remains the gold standard treatment for "end-stage" dilated cardiomyopathy. However, its epidemiologic impact on the heart failure problem continues to be small due to limited donor organ availability and contraindications. Therefore, several "conventional" surgical procedures have been developed to reverse the vicious cycle of ventricular remodeling that accompanies systolic heart failure and to improve symptoms and survival of the patients. This review discusses indications, results, and limitations of the most common surgical methods currently used to arrest or reverse cardiac remodeling.
Related Concept Videos
Cardiomyopathy V: Interprofessional Care
Aortic Regurgitation III: Medical Management
Mitral Stenosis III: Medical Management
Cardiomyopathy II: Dilated Cardiomyopathy
