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High-performance liquid chromatographic analysis of chlorhexidine phosphanilate, a new antimicrobial agent
R R Gadde1, E F McNiff, M M Peer
1Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Buffalo, NY 14213.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1991
Abstract:
Chlorhexidine phosphanilate (CHP) is analysed by two separate reversed-phase HPLC methods. CHP was found to be a non-stoichiometric compound with a phosphanilic acid to chlorhexidine ratio of 1.83. By careful choice of solvents, solution pH and HPLC columns, loss of sample due to incomplete dissolution and adsorption to surfaces is avoided. Both methods are shown to be stability-indicating and accurate.