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Updated: Jul 7, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
[Primary progressive aphasia: a specific consideration among the neurodegenerative pathology]
Introduction:
Isolated progressive speech and language difficulties are often the first symptom of primary progressive aphasia.
Exegesis:
We report a 63-year-old woman with progressive language impairment that remained isolated for at least two years, related to a greater atrophy within the left hemisphere. There was no impairment in daily living during two years and six months. Progressively, she developed a frontal dementia.
Conclusion:
Isolated language impairment may be the inaugural symptom of a focal form of a neurodegenerative disease. Progressive language deterioration without impairment in daily life activity or behavioral changes must be differentiated from Alzheimer disease. Brain imaging is important for the diagnosis.
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