Related Experiment Video
Updated: Jul 7, 2026
13:26
Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
Published on: August 11, 2016
Probabilistic diffusion tractography of the optic radiations and visual function in preterm infants at term
Laura Bassi1, Daniela Ricci, Anna Volzone
1NICU, Institute of Pediatrics and Neonatology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Italy.
Brain : a Journal of Neurology
|January 29, 2008
Summary
Visual function in preterm infants is linked to white matter development in the optic radiations. Diffusion tensor imaging revealed fractional anisotropy in these tracts correlates with visual abilities at term equivalent age.
Area of Science:
- Neuroscience
- Pediatrics
- Ophthalmology
Background:
- Preterm infants often experience visual disorders not fully explained by retinal or brain lesions.
- Understanding the neurobiological basis of visual impairment in this population is crucial.
Purpose of the Study:
- To investigate the relationship between white matter microstructural development in the optic radiations and visual function in preterm infants.
- To test the hypothesis that visual function is associated with the development of the optic radiations.
Main Methods:
- Diffusion tensor imaging (DTI) and probabilistic tractography were used to delineate optic radiations in preterm infants at term equivalent age.
- Fractional anisotropy (FA) values of the optic radiations were correlated with a comprehensive visual assessment score.
- Conventional MRI was used to assess for cerebral lesions.
Main Results:
- Visual assessment scores were independently correlated with FA values in the optic radiations.
- Gestational age, post-menstrual age at scan, and presence of cerebral lesions did not independently correlate with visual function.
- Only FA in the optic radiations, not global white matter, correlated with visual assessment scores.
Conclusions:
- Visual function in preterm infants at term equivalent age is directly related to the microstructural development of white matter in the optic radiations.
- DTI provides valuable insights into the neuroanatomical underpinnings of visual deficits in this vulnerable group.
